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Primary Anorectal Amelanotic Melanoma: The First Case Report from Saudi Arabia
- Source :
- Middle East Journal of Digestive Diseases, Vol 11, Iss 3, Pp 166-173 (2019)
- Publication Year :
- 2019
- Publisher :
- Iranian Association of Gastroenterology and Hepatology, Shiraz University of Medical Sciences, 2019.
-
Abstract
- Anorectal melanomas are exceptionally uncommon and only 30% of anorectal melanomas are amelanotic. We report here a case of an anorectal amelanotic melanoma in a female patient. An 84-year-old patient complained of anal mass for 3 months. On examination, there was a 7.0 cm mass prolapsing through the anus that was pale-pink in color. Abdominal, pelvic, and chest computed tomography (CT) showed rectal wall thickening with an eccentric polypoid soft tissue density mass, and left inguinal and presacral lymph node enlargement along with a small nodule in the lower lobe of the left lung, likely representing metastatic deposit. Microscopic examination revealed a piece of skin with hyperplastic squamous epithelium with surface ulceration. The dermis and underlining tissue were showing infiltration by malignant sheets and nests of ovoid and spindle shape cells with prominent nucleolus and high mitotic s. Immuno-staining for HMB-45, S-100, and Melan-A was positive, and it was negative for P63, CK 5/6, and Pan-CK, thus confirming it as an anorectal amelanotic melanoma, and not an epithelial tumor. This is the first case of an amelanotic anorectal melanoma reported from Saudi Arabia.
- Subjects :
- Anorectal cancer
Anorectal melanoma
Amelanotic melanoma
Lung metastasis
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 20085230 and 20085249
- Volume :
- 11
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Middle East Journal of Digestive Diseases
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f71f787b6ef647c2a6c78eae4d42df64
- Document Type :
- article
- Full Text :
- https://doi.org/10.15171/mejdd.2019.144