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The biological activity of Ocimum minimum L. flowers on redox status parameters in HCT-116 colorectal carcinoma cells

Authors :
Jovankić Jovana V.
Nikodijević Danijela D.
Blagojević Stefan Z.
Radenković Nikola M.
Jakovljević Dragana Z.
Grbović Filip J.
Cvetković Danijela M.
Source :
Kragujevac Journal of Science, Vol 2022, Iss 44, Pp 155-168 (2022)
Publication Year :
2022
Publisher :
University of Kragujevac, Faculty of Science, 2022.

Abstract

Medicinal plants have widely been used as a natural source of remedies for treating several diseases, including colorectal cancer. Ocimum minimum L. is a very important dietary plant used in traditional and modern medicine, due to its health beneficial effect realized by cytotoxic, proapoptotic, antioxidant/prooxidant, antiviral and antimicrobial activity. The biological activity of O. minimum flowers has been evaluated in HCT116 colorectal carcinoma cells through antiproliferative activity by MTT assay, pro-apoptotic activity by AO/EB and concentrations of redox status parameters (O2∙ and lipid peroxidation) by colorimetric methods. The protein expression of iNOS was analyzed by immunocytochemistry, while the antimigratory effect was measured by xCELLigence system. The treatment with O. minimum shows the antiproliferative, proapoptotic, impact on redox status parameters and antimigratory effect on HCT-116 cells. Based on obtained results, the pharmacological effect of O. minimum is evident against HCT-116 colorectal carcinoma cells, suggesting that this plant may be good start material for future anticancer therapy investigation.

Details

Language :
English
ISSN :
14509636 and 24665509
Volume :
2022
Issue :
44
Database :
Directory of Open Access Journals
Journal :
Kragujevac Journal of Science
Publication Type :
Academic Journal
Accession number :
edsdoj.f6b9cc895624bb385d8d02ed0b0b0c5
Document Type :
article
Full Text :
https://doi.org/10.5937/KgJSci2244155J