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Association between TP53 mutation and high 21-gene recurrence score in estrogen receptor-positive/HER2-negative breast cancer

Authors :
Jung Hwan Ji
Soong June Bae
Kyungsoo Kim
Chihhao Chu
Kyung-A Lee
Yoonjung Kim
Jee Hung Kim
Joon Jeong
Sung Gwe Ahn
Source :
npj Breast Cancer, Vol 8, Iss 1, Pp 1-7 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Abstract We investigated the association between TP53 mutation and 21-gene recurrence score (RS) in ER-positive/HER2-negative breast cancer (BC) using data from 141 patients who underwent TP53 sequencing and Oncotype DX® tests. We detected TP53 mutations in 18 (12.8%) patients. Most patients with TP53 mutation had a high 21-gene RS (≥26). The average 21-gene RS was higher in TP53 mutant tumors. Multivariate analysis showed that mutated TP53 is an independent factor for a high 21-gene RS. Mutated TP53 remained closely associated with high 21-gene RS in patients with low pathological risk (n = 103). In the ER+/PR+/HER2-negative subset (n = 356) of The Cancer Genome Atlas, the non-luminal A intrinsic subtype was more prevalent in the group with mutant TP53. mRNA levels of p53-regulated senescence gatekeeper and cell cycle-related genes were increased in BC with mutated TP53. Mutational analysis of TP53 helped identify endocrine-resistant tumors.

Details

Language :
English
ISSN :
23744677
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
npj Breast Cancer
Publication Type :
Academic Journal
Accession number :
edsdoj.f67d71b9ef04f029add763cab589197
Document Type :
article
Full Text :
https://doi.org/10.1038/s41523-022-00384-3