Back to Search Start Over

Prognostic Impact of Postoperative Complications in High-Risk Operable Non-small Cell Lung Cancer

Authors :
Seungwook Lee
Md Roknuggaman
Jung A Son
Seungji Hyun
Joonho Jung
Seokjin Haam
Woo Sik Yu
Source :
Journal of Chest Surgery, Vol 55, Iss 1, Pp 20-29 (2022)
Publication Year :
2022
Publisher :
Korean Society for Thoracic & Cardiovascular Surgery, 2022.

Abstract

Background: Patients with high-risk (HR) operable non-small cell lung cancer (NSCLC) may have unique prognostic factors. This study aimed to evaluate surgical outcomes in HR patients and to investigate prognostic factors in HR patients versus standard-risk (SR) patients. Methods: In total, 471 consecutive patients who underwent curative lung resection for NSCLC between January 2012 and December 2017 were identified and reviewed retrospectively. Patients were classified into HR (n=77) and SR (n=394) groups according to the American College of Surgeons Oncology Group criteria (Z4099 trial). Postoperative complications were defined as those of grade 2 or higher by the Clavien-Dindo classification. Results: The HR group comprised more men and older patients, had poorer lung function, and had more comorbidities than the SR group. The patients in the HR group also experienced more postoperative complications (p≤0.001). More HR patients died without disease recurrence. The postoperative complication rate was the only significant prognostic factor in multivariable Cox regression analysis for HR patients but not SR patients. HR patients without postoperative complications had a survival rate similar to that of SR patients. Conclusion: The overall postoperative survival of HR patients with NSCLC was more strongly affected by postoperative complications than by any other prognostic factor. Care should be taken to minimize postoperative complications, especially in HR patients.

Details

Language :
English
ISSN :
27651606 and 27651614
Volume :
55
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Chest Surgery
Publication Type :
Academic Journal
Accession number :
edsdoj.f649bf2203944d78ad11b4059d1669eb
Document Type :
article
Full Text :
https://doi.org/10.5090/jcs.21.100