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Assessment of interleukin-18 gene polymorphism and serum levels in cutaneous lichen planus
- Source :
- European Journal of Medical Research, Vol 29, Iss 1, Pp 1-7 (2024)
- Publication Year :
- 2024
- Publisher :
- BMC, 2024.
-
Abstract
- Abstract Background Lichen planus (LP) is a chronic inflammatory disease with uncertain etiology. Interleukin-18 (IL-18) is an interferon gamma (INFγ) inducing agent. It is a pro-inflammatory cytokine that was found to play a role in the pathogenesis of some autoimmune disorders. Material and methods This study included 50 patients with classic cutaneous lichen planus (CLP) and 50 healthy volunteers serving as controls. Venous blood samples were withdrawn from the study subjects under complete aseptic precautions. Blood samples were examined for single nucleotide polymorphisms (SNPs) of IL-18 gene at promoter -137(G/C) and -656 (G/T) using polymerase chain reaction (PCR) and IL-18 level was assessed using enzyme linked immunosorbent assay (ELISA). Results The mean level of IL-18 was significantly higher in CLP patients (31.63 ± 4.90) compared to control subjects (13.95 ± 6.82). Significantly high levels of IL-18 were found among patients with diabetes, hypertension (p
- Subjects :
- Lichen planus
Autoinflammatory disorders
Cytokines
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 2047783X
- Volume :
- 29
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- European Journal of Medical Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f635ebf559e4a18b3234bf7e05c4ddb
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s40001-024-01846-z