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A Randomised Controlled Trial of the Efficacy and Safety of 0.25% Desoximetasone Cream (Topoxy) Compared with 0.25% Desoximetasone Cream (Topicorte) for the Treatment of Scalp Psoriasis
- Source :
- Siriraj Medical Journal, Vol 72, Iss 5 (2020)
- Publication Year :
- 2020
- Publisher :
- Faculty of Medicine Siriraj Hospital, 2020.
-
Abstract
- Objective: To compare the efficacy and safety of a generic desoximetasone cream (Topoxy) with the reference form, Topicorte, for the treatment of scalp psoriasis. Methods: A randomised, double-blind, controlled study was conducted. Altogether, 105 patients with psoriasis lesions covering more than 10% of the scalp were randomised into three groups. The first, second and third groups received a placebo, Topoxy and Topicorte, respectively. The scalp psoriasis severities were assessed at weeks 0, 2, 4 and 8, using the Investigator Global Assessment (IGA) scale and Total Sign Score (TSS). The safety profiles of the products were assessed by the patients and physicians. Results: Topoxy and Topicorte were significantly more effective than the placebo in achieving at least a two-grade improvement in the IGA score from baseline at weeks 2, 4 and 8, and there were no significant differences between Topoxy and Topicorte. The TSS of both creams were significantly lower than that of the placebo at weeks 2, 4 and 8. All patients tolerated well to the therapy. Conclusion: Topoxy and Topicorte had comparable efficacies for scalp psoriasis., The medications were superior to the placebo in all parameters, and had a good safety profile.
- Subjects :
- Desoximetasone cream
scalp psoriasis
topicorte
topoxy
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 22288082
- Volume :
- 72
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- Siriraj Medical Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f625f5728c8a4588a418bbc38923de16
- Document Type :
- article
- Full Text :
- https://doi.org/10.33192/Smj.2020.50