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Data supporting the effects of xanthine derivative KMUP-3 on vascular smooth muscle cell calcification and abdominal aortic aneurysm in mice

Authors :
Chao-Han Lai
Ching-Wen Chang
Fang-Tzu Lee
Cheng-Hsiang Kuo
Jong-Hau Hsu
Chung-Pin Liu
Hua-Lin Wu
Jwu-Lai Yeh
Source :
Data in Brief, Vol 30, Iss , Pp 105550- (2020)
Publication Year :
2020
Publisher :
Elsevier, 2020.

Abstract

No pharmacotherapy in the clinical setting has been available to alter the natural history of abdominal aortic aneurysm (AAA). Targeting vascular smooth muscle cell (VSMC) dysfunction during the pathogenesis of AAA, including phenotypic switch and apoptosis, could be a potential strategy to limit AAA growth. Here, we provide additional information regarding materials, methods and data related to our recent study published in Atherosclerosis [1]. The therapeutic potential of a self-developed xanthine derivative KMUP-3 was evaluated in VSMC calcification and abdominal aortic aneurysm (AAA). In vitro VSMC calcification was induced using β-glycerophosphate, and AAA was induced using angiotensin II infusion for 4 weeks in apolipoprotein E-deficient mice. The data contained in this article support the effects of KMUP-3 on VSMC calcification and AAA.

Details

Language :
English
ISSN :
23523409
Volume :
30
Issue :
105550-
Database :
Directory of Open Access Journals
Journal :
Data in Brief
Publication Type :
Academic Journal
Accession number :
edsdoj.f5fc319d7e4585a48bf513f0b21c6e
Document Type :
article
Full Text :
https://doi.org/10.1016/j.dib.2020.105550