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Data supporting the effects of xanthine derivative KMUP-3 on vascular smooth muscle cell calcification and abdominal aortic aneurysm in mice
- Source :
- Data in Brief, Vol 30, Iss , Pp 105550- (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- No pharmacotherapy in the clinical setting has been available to alter the natural history of abdominal aortic aneurysm (AAA). Targeting vascular smooth muscle cell (VSMC) dysfunction during the pathogenesis of AAA, including phenotypic switch and apoptosis, could be a potential strategy to limit AAA growth. Here, we provide additional information regarding materials, methods and data related to our recent study published in Atherosclerosis [1]. The therapeutic potential of a self-developed xanthine derivative KMUP-3 was evaluated in VSMC calcification and abdominal aortic aneurysm (AAA). In vitro VSMC calcification was induced using β-glycerophosphate, and AAA was induced using angiotensin II infusion for 4 weeks in apolipoprotein E-deficient mice. The data contained in this article support the effects of KMUP-3 on VSMC calcification and AAA.
Details
- Language :
- English
- ISSN :
- 23523409
- Volume :
- 30
- Issue :
- 105550-
- Database :
- Directory of Open Access Journals
- Journal :
- Data in Brief
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f5fc319d7e4585a48bf513f0b21c6e
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.dib.2020.105550