The Screening Value Of ESS, SACS, BQ, And SBQ On Obstructive Sleep Apnea In Patients With Chronic Obstructive Pulmonary Disease

Mengqing Xiong,1 Weihua Hu,1 Minglin Dong,1 Meifang Wang,2 Junwen Chen,3 Hanzhong Xiong,4 Minhua Zhong,5 Yan Jiang,6 Dan Liu,6 Ke Hu1 1Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, People’s Republic of China; 3Department of Respiratory and Critical Care Medicine, Xiangyang Hospital, Hubei University of Medicine, Xiangyang 441000, People’s Republic of China; 4Department of Respiratory and Critical Care Medicine, Ezhou Central Hospital, Ezhou 436000, People’s Republic of China; 5Department of Respiratory and Critical Care Medicine, Xiaogan Central Hospital, Wuhan University of Technology, Xiaogan 432000, People’s Republic of China; 6Division of Respiratory Disease, The Fifth Hospital of Wuhan City, Wuhan 430050, People’s Republic of ChinaCorrespondence: Ke HuDepartment of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Zhangzhidong Road, No. 99, Wuhan 430060, People’s Republic of ChinaTel +86 189 7103 5988Fax +86 27 8804 2292Email huke-rmhospital@163.comObjective: To compare the performance of Epworth sleepiness scale (ESS), sleep apnea clinical score (SACS), Berlin questionnaire (BQ), and STOP-BANG questionnaire (SBQ) in screening for obstructive sleep apnea (OSA) in patients with chronic obstructive pulmonary disease (COPD).Methods: A total of 431 patients were analyzed. All subjects completed lung function test, ESS, SACS, BQ, and SBQ survey and overnight polysomnography (PSG). According to lung function and PSG results, participants were divided into COPD with OSA group (OVS, AHI ≥5) and without OSA group (AHI 2 was considered high risk of OSA; the sensitivity, specificity, and AUC were 92.8%, 40.6%, and 0.723 respectively, the odds ratio (OR) was 2.161. When AHI ≥15, AUC for SBQ was 0.737. In predicting severe OSA (AHI ≥30), the ROC curve showed cut-off point, sensitivity, specificity, and AUC for SBQ was >4, 66.1%, 82.1%, and 0.824 respectively; the positive and negative likelihood ratio was 3.70, 0.41 separately, the OR was 2.977.Conclusion: SBQ performed better than ESS, SACS, and BQ in predicting OSA in patients with COPD.Keywords: Berlin questionnaire, STOP-BANG questionnaire