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Identification of fibrosis-associated biomarkers in heart failure and human cancers

Authors :
Can Hou
Junyu Huo
Si Yan
Fei Sun
Xiaoyu Yang
Source :
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Publication Year :
2024
Publisher :
BMC, 2024.

Abstract

Abstract Background Heart failure (HF) and cancer share common risk factors and pathophysiological mechanisms, including fibrosis. Identifying biomarkers and therapeutic targets for both conditions is crucial. Materials and methods RNA sequencing data from HF patients were analyzed to identify 12 genes associated with myocardial fibrosis. Validation was performed using public datasets, and functional enrichment analyses were conducted. Gene expression patterns and prognostic value in various cancers were assessed. Results Fibromodulin (FMOD), Periostin (POSTN), Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2), Collagen Type I Alpha 1 Chain (COL1A1), Collagen Type VIII Alpha 1 Chain (COL8A1), Asporin (ASPN), and Hemoglobin Subunit Beta (HBB) showed significant dysregulation in heart failure tissues and were implicated in multiple cancer types. Pan-cancer analysis revealed associations between these genes and prognosis. Correlations with cancer-associated fibroblasts were also observed. Conclusion FMOD, POSTN, LTBP2, COL1A1, COL8A1, ASPN, and HBB are potential biomarkers for HF and cancer with fibrotic microenvironments. Targeting fibrosis may offer novel therapeutic approaches. Further validation and mechanistic studies are needed. This study contributes to understanding HF and cancer at the molecular level and suggests personalized treatment strategies.

Details

Language :
English
ISSN :
14795876
Volume :
22
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Translational Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.f5a3fef4f13c45f6ae7928338ba5cefd
Document Type :
article
Full Text :
https://doi.org/10.1186/s12967-024-05759-7