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Assessment of pharmacokinetics, safety, and tolerability following twice‐daily administration of molnupiravir for 10 days in healthy participants
- Source :
- Clinical and Translational Science, Vol 16, Iss 10, Pp 1947-1956 (2023)
- Publication Year :
- 2023
- Publisher :
- Wiley, 2023.
-
Abstract
- Abstract Molnupiravir is an orally administered, small‐molecule ribonucleoside prodrug of β‐D‐N4‐hydroxycytidine (NHC) that has demonstrated potent, broad‐spectrum preclinical activity against RNA viruses and has a high barrier to the development of resistance. A double‐blind, placebo‐controlled, phase I trial was conducted to evaluate the pharmacokinetics (PKs), safety, and tolerability of 10.5‐day administration of multiple doses of molnupiravir and its metabolites in healthy, adult participants. Participants were randomly assigned (3:1) to receive molnupiravir (400 mg [n = 6], 600 mg [n = 6], and 800 mg [n = 12]) or matching placebo (n = 8) every 12 h (q12h) for 10.5 days. Blood was collected to evaluate the PKs of NHC in plasma and of its active metabolite, NHC‐triphosphate (NHC‐TP), in peripheral blood mononuclear cells (PBMCs). Molnupiravir was generally well‐tolerated. All adverse events were mild or moderate in severity and none led to treatment discontinuation. No clinically meaningful dose‐related safety findings were observed. Mean time to maximal concentration was ~1.50 to 1.98 h for plasma NHC and ~4.00 to 8.06 h for PBMC NHC‐TP. Accumulation was minimal (
- Subjects :
- Therapeutics. Pharmacology
RM1-950
Public aspects of medicine
RA1-1270
Subjects
Details
- Language :
- English
- ISSN :
- 17528062 and 17528054
- Volume :
- 16
- Issue :
- 10
- Database :
- Directory of Open Access Journals
- Journal :
- Clinical and Translational Science
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f55f7be76e6247dbb0db33febe23a640
- Document Type :
- article
- Full Text :
- https://doi.org/10.1111/cts.13602