Cell-free DNA as a novel diagnostic biomarker for periodontitis

Periodontitis, a common inflammatory disease affecting the periodontal tissue, poses diagnostic and management challenges. Conventional methods are not capable of assessing disease activity or identifying individuals who are prone to progression. Biomarkers, measurable substances that indicate the presence, severity, or progression of disease, offer a promising approach to diagnosing periodontitis. Recent discoveries in molecular diagnostics have prompted the search for novel biomarkers, including cell-free DNA (cfDNA). This review article gives an insight into current knowledge regarding the use of cfDNA as a diagnostic marker in periodontal disease diagnosis.