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Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose

Authors :
Laurent Renia
Yun Shan Goh
Angeline Rouers
Nina Le Bert
Wan Ni Chia
Jean-Marc Chavatte
Siew‐Wai Fong
Zi Wei Chang
Nicole Ziyi Zhuo
Matthew Zirui Tay
Yi-Hao Chan
Chee Wah Tan
Nicholas Kim‐Wah Yeo
Siti Naqiah Amrun
Yuling Huang
Joel Xu En Wong
Pei Xiang Hor
Chiew Yee Loh
Bei Wang
Eve Zi Xian Ngoh
Siti Nazihah Mohd Salleh
Guillaume Carissimo
Samanzer Dowla
Alicia Jieling Lim
Jinyan Zhang
Joey Ming Er Lim
Cheng-I. Wang
Ying Ding
Surinder Pada
Louisa Jin Sun
Jyoti Somani
Eng Sing Lee
Desmond Luan Seng Ong
SCOPE Cohort Study Group
Yee‐Sin Leo
Paul A. MacAry
Raymond Tzer Pin Lin
Lin-Fa Wang
Ee Chee Ren
David C. Lye
Antonio Bertoletti
Barnaby Edward Young
Lisa F. P. Ng
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Responses to SARS-CoV-2 vaccines in different populations are important to define efficacy. Here the authors show using a cohort in Singapore that two doses of mRNA vaccine is less effective in recipients over 60 years of age and that a further dose of vaccine can improve these antibody levels.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.f557f150209f4990850aaa97c4f0f4e6
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-32312-1