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Preliminary Simulation Study of Carotid Artery and Pharyngeal Constrictor Muscle Sparing-Radiotherapy in Glottic Carcinoma

Authors :
Yurday Ozdemir MD
Ibrahim Acibuci PhD
Ugur Selek MD
Erkan Topkan MD
Source :
Technology in Cancer Research & Treatment, Vol 19 (2020)
Publication Year :
2020
Publisher :
SAGE Publishing, 2020.

Abstract

Background: This preliminary simulation study aimed to compare the dosimetric outcomes of carotid arteries (CAs) and pharyngeal constrictor muscle (PCM) in patients with T1N0M0 glottic carcinoma undergoing helical tomotherapy-intensity modulated radiotherapy (HT-IMRT) and 3-dimensional conformal radiotherapy (3D-CRT) plans. Methods: In addition to the clinical target volume (CTV) which was defined as the entire larynx, the CAs and PCM of 11 glottic carcinoma patients were delineated. The CTV was uniformly expanded 5 mm to create a planning target volume (PTV) relative to the PCM and at a distance of 2 mm from the CA. The dosimetric characteristics in HT-IMRT and lateral opposed fields-based 3D-CRT plans were analyzed. Results: Median D 95% and V 100% of PTV were significantly higher in HT-IMRT (p < 0.001) compared to 3D-CRT. The right/left CA dosimetric outcomes, including the mean doses (20.7/21.5 Gy versus 48.7/50.5 Gy), D max (53.6/52.0 Gy versus 67.4/67.7 Gy), V 30 (25.0/27.1% versus 77.6/80.3%), V 40 (8.0/7.9% versus 74.6/71.9%), and V 50 (2.0/1.2% versus 70.0/71.6%) were also significantly lower in HT-IMRT (p < 0.05), similar to the mean PCM doses (49.6 Gy versus 62.6 Gy for 3D-CRT;p < 0.001), respectively. Conclusions: Our present results demonstrated the feasibility of simultaneous sparing of the CAs and PCM in HT-IMRT- compared to 3D-CRT plans in glottic carcinoma patients undergoing definitive radiotherapy.

Details

Language :
English
ISSN :
15330338
Volume :
19
Database :
Directory of Open Access Journals
Journal :
Technology in Cancer Research & Treatment
Publication Type :
Academic Journal
Accession number :
edsdoj.f52b4b6f31a465c8a52d9acc3d4d8f3
Document Type :
article
Full Text :
https://doi.org/10.1177/1533033820956989