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Accuracy of Real Time Continuous Glucose Monitoring during Different Liquid Solution Challenges in Healthy Adults: A Randomized Controlled Cross-Over Trial

Authors :
Janis R. Schierbauer
Svenja Günther
Sandra Haupt
Rebecca T. Zimmer
Beate E. M. Zunner
Paul Zimmermann
Nadine B. Wachsmuth
Max L. Eckstein
Felix Aberer
Harald Sourij
Othmar Moser
Source :
Sensors, Vol 22, Iss 9, p 3104 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Continuous glucose monitoring (CGM) represents an integral of modern diabetes management, however, there is still a lack of sensor performance data when rapidly consuming different liquids and thus changing total body water. 18 healthy adults (ten females, age: 23.1 ± 1.8 years, BMI 22.2 ± 2.1 kg·m−2) performed four trial visits consisting of oral ingestion (12 mL per kg body mass) of either a 0.9% sodium chloride, 5% glucose or Ringer’s solution and a control visit, in which no liquid was administered (control). Sensor glucose levels (Dexcom G6, Dexcom Inc., San Diego, CA, USA) were obtained at rest and in 10-min intervals for a period of 120 min after solution consumption and compared against reference capillary blood glucose measurements. The overall MedARD [IQR] was 7.1% [3.3–10.8]; during control 5.9% [2.7–10.8], sodium chloride 5.0% [2.7–10.2], 5% glucose 11.0% [5.3–21.6] and Ringer’s 7.5% [3.1–13.2] (p < 0.0001). The overall bias [95% LoA] was 4.3 mg·dL−1 [−19 to 28]; during control 3.9 mg·dL−1 [−11 to 18], sodium chloride 4.8 mg·dL−1 [−9 to 19], 5% glucose 3.6 mg·dL−1 [−33 to 41] and Ringer’s solution 4.9 mg·dL−1 [−13 to 23]. The Dexcom G6 CGM system detects glucose with very good accuracy during liquid solution challenges in normoglycemic individuals, however, our data suggest that in people without diabetes, sensor performance is influenced by different solutions.

Details

Language :
English
ISSN :
14248220
Volume :
22
Issue :
9
Database :
Directory of Open Access Journals
Journal :
Sensors
Publication Type :
Academic Journal
Accession number :
edsdoj.f4f4adde2324ad592e99b03e615e219
Document Type :
article
Full Text :
https://doi.org/10.3390/s22093104