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Predictive Factors for Delivery within 7 Days after Successful 48-Hour Treatment of Threatened Preterm Labor

Authors :
Carolien Roos
Ewoud Schuit
Hubertina C. J. Scheepers
Kitty W. M. Bloemenkamp
Antoinette C. Bolte
Hans J. J. Duvekot
Jim van Eyck
Joke H. Kok
Anneke Kwee
Ashley E. R. Merién
Brent C. Opmeer
Martijn A. Oudijk
Mariëlle G. van Pampus
Dimitri N. M. Papatsonis
Martina M. Porath
Krystyna M. Sollie
Marc E. A. Spaanderman
Sylvia M. C. Vijgen
Christine Willekes
Fred K. Lotgering
Joris A. M. van der Post
Ben Willem J. Mol
Source :
American Journal of Perinatology Reports, Vol 05, Iss 02, Pp e141-e149 (2015)
Publication Year :
2015
Publisher :
Thieme Medical Publishers, Inc., 2015.

Abstract

Abstract Objective The aim of this study was to assess which characteristics and results of vaginal examination are predictive for delivery within 7 days, in women with threatened preterm labor after initial treatment. Study Design A secondary analysis of a randomized controlled trial on maintenance nifedipine includes women who remained undelivered after threatened preterm labor for 48 hours. We developed one model for women with premature prelabor rupture of membranes (PPROM) and one without PPROM. The predictors were identified by backward selection. We assessed calibration and discrimination and used bootstrapping techniques to correct for potential overfitting. Results For women with PPROM (model 1), nulliparity, history of preterm birth, and vaginal bleeding were included in the multivariable analysis. For women without PPROM (model 2), maternal age, vaginal bleeding, cervical length, and fetal fibronectin (fFN) status were in the multivariable analysis. Discriminative capability was moderate to good (c-statistic 0.68; 95% confidence interval [CI] 0.60–0.77 for model 1 and 0.89; 95% CI, 0.84–0.93 for model 2). Conclusion PPROM and vaginal bleeding in the current pregnancy are relevant predictive factors in all women, as are maternal age, cervical length, and fFN in women without PPROM and nulliparity, history of preterm birth in women with PPROM.

Details

Language :
English
ISSN :
21576998 and 21577005
Volume :
05
Issue :
02
Database :
Directory of Open Access Journals
Journal :
American Journal of Perinatology Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.f4d636fb669f4ddda836f0c064ca9324
Document Type :
article
Full Text :
https://doi.org/10.1055/s-0035-1552930