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Initial success from a public health approach to hepatitis C testing, treatment and cure in seven countries: the road to elimination

Authors :
Nguyen Van Kinh
Sabin Nsanzimana
Alida Ngwije
Caroline E Boeke
Clement Adesigbin
Chukwuemeka Agwuocha
Atiek Anartati
Hlaing Thazin Aung
Khin Sanda Aung
Gagandeep Singh Grover
Dang Ngo
Emi Okamoto
Siddharth Sindhwani
Grace Singh
Ly Penh Sun
Wiendra Waworuntu
Craig McClure
Source :
BMJ Global Health, Vol 5, Iss 12 (2020)
Publication Year :
2020
Publisher :
BMJ Publishing Group, 2020.

Abstract

With political will, modest financial investment and effective technical assistance, public sector hepatitis C virus (HCV) programmes can be established in low- and middle-income countries as a first step towards elimination. Seven countries, with support from the Clinton Health Access Initiative (CHAI) and partners, have expanded access to HCV treatment by combining programme simplification with market shaping to reduce commodity prices. CHAI has supported a multipronged approach to HCV programme launch in Cambodia, India, Indonesia, Myanmar, Nigeria, Rwanda and Vietnam including pricing negotiations with suppliers, policy development, fast-track registrations of quality-assured generics, financing advocacy and strengthened service delivery. Governments are leading programme implementation, leveraging HIV programme infrastructure/financing and focusing on higher-HCV prevalence populations like people living with HIV, people who inject drugs and prisoners. This manuscript aims to describe programme structure and strategies, highlight current commodity costs and outline testing and treatment volumes across these countries. Across countries, commodity costs have fallen from >US$100 per diagnostic test and US$750–US$900 per 12-week pan-genotypic direct-acting antiviral regimen to as low as US$80 per-cure commodity package, including WHO-prequalified generic drugs (sofosbuvir + daclatasvir). As of December 2019, 5900+ healthcare workers were trained, 2 209 209 patients were screened, and 120 522 patients initiated treatment. The cure (SVR12) rate was >90%, including at lower-tier facilities. Programmes are successfully implementing simplified, decentralised public health approaches. Combined with political will and affordable pricing, these efforts can translate into commitments to achieve global targets. However, to achieve elimination, additional investment in scale-up is required.

Details

Language :
English
ISSN :
20597908
Volume :
5
Issue :
12
Database :
Directory of Open Access Journals
Journal :
BMJ Global Health
Publication Type :
Academic Journal
Accession number :
edsdoj.f471e9e760d4084b499c117013383ba
Document Type :
article
Full Text :
https://doi.org/10.1136/bmjgh-2020-003767