Correlation between body mass index and gender-specific 28-day mortality in patients with sepsis: a retrospective cohort study

ObjectiveTo investigate the potential correlation between body mass index (BMI) and the 28-day mortality rate among sepsis patients and the gender difference in this association.DesignThe current research was a retrospective cohort study.ParticipantsA total of 14,883 male and female cohorts of sepsis patients were included in the Medical Information Mart for Intensive Care IV (MIMIC-IV V2.2) database. Patients in each gender cohort were further classified as underweight, normal weight, overweight, or obese according to BMI and the World Health Organization (WHO) BMI categories.OutcomesThe 28-day mortality from the date of ICU hospitalization was the primary outcome measure.ResultsThe BMI and 28-day mortality exhibited an L-shaped relationship (p for nonlinearity