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LncRNAs LY86-AS1 and VIM-AS1 Distinguish Plasma Cell Leukemia Patients from Multiple Myeloma Patients

Authors :
Romana Bútová
Petra Vychytilová-Faltejsková
Jana Gregorová
Lenka Radová
Martina Almáši
Renata Bezděková
Lucie Brožová
Jiří Jarkovský
Zdeňka Knechtová
Martin Štork
Luděk Pour
Sabina Ševčíková
Source :
Biomedicines, Vol 9, Iss 11, p 1637 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Long non-coding RNAs (lncRNAs) are functional RNAs longer than 200 nucleotides. Due to modern genomic techniques, the involvement of lncRNAs in tumorigenesis has been revealed; however, information concerning lncRNA interplay in multiple myeloma (MM) and plasma cell leukemia (PCL) is virtually absent. Herein, we aimed to identify the lncRNAs involved in MM to PCL progression. We investigated representative datasets of MM and PCL patients using next-generation sequencing. In total, 13 deregulated lncRNAs (p

Details

Language :
English
ISSN :
22279059
Volume :
9
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.f43e6c946a264e1f92f59c50de106207
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines9111637