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Impaired sharp-wave ripple coordination between the medial entorhinal cortex and hippocampal CA1 of knock-in model of Alzheimer’s disease

Authors :
Tsukasa Funane
Heechul Jun
Stephanie Sutoko
Takaomi C. Saido
Akihiko Kandori
Kei M. Igarashi
Source :
Frontiers in Systems Neuroscience, Vol 16 (2022)
Publication Year :
2022
Publisher :
Frontiers Media S.A., 2022.

Abstract

Clinical evidence suggests that the entorhinal cortex is a primary brain area triggering memory impairments in Alzheimer’s disease (AD), but the underlying brain circuit mechanisms remain largely unclear. In healthy brains, sharp-wave ripples (SWRs) in the hippocampus and entorhinal cortex play a critical role in memory consolidation. We tested SWRs in the MEC layers 2/3 of awake amyloid precursor protein knock-in (APP-KI) mice, recorded simultaneously with SWRs in the hippocampal CA1. We found that MEC→CA1 coordination of SWRs, found previously in healthy brains, was disrupted in APP-KI mice even at a young age before the emergence of spatial memory impairments. Intriguingly, long-duration SWRs critical for memory consolidation were mildly diminished in CA1, although SWR density and amplitude remained intact. Our results point to SWR incoordination in the entorhinal-hippocampal circuit as an early network symptom that precedes memory impairment in AD.

Details

Language :
English
ISSN :
16625137
Volume :
16
Database :
Directory of Open Access Journals
Journal :
Frontiers in Systems Neuroscience
Publication Type :
Academic Journal
Accession number :
edsdoj.f436e5f053a451fa91ad306caf0549d
Document Type :
article
Full Text :
https://doi.org/10.3389/fnsys.2022.955178