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Effects of carbamazepine on serum parathormone, 25- hydroxyvitamin D, bone specific alkaline phosphatase, C-telopeptide, and osteocalcin levels in healthy rats
- Source :
- Biomolecules & Biomedicine, Vol 12, Iss 4 (2012)
- Publication Year :
- 2012
- Publisher :
- Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina, 2012.
-
Abstract
- It is still not completely clear whether carbamazepine causes alterations in vitamin D status and in bone metabolism. The objective of this study was to investigate the effects of carbamazepine on serum levels of 25-hydroxyvitamin D and on biomarkers of bone formation and resorption in healthy rats. Levels of calcium, 25-hydroxyvitamin D, parathormone, C-telopeptide, bone specific alkaline phosphatase and osteocalcin were measured in 3 groups of rats consisting of controls (n=10), isotonic saline solution group (n=10) and carbamazepine group (n=10). Mean calcium levels were found to be significantly lower in healthy controls in comparison to isotonic saline solution and carbamazepine groups (10.0±0.24, 10.81±0.16, 10.93±0.22 mg/dL, respectively, p
Details
- Language :
- English
- ISSN :
- 28310896 and 2831090X
- Volume :
- 12
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Biomolecules & Biomedicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f43334813d614418afa564759342b5d7
- Document Type :
- article
- Full Text :
- https://doi.org/10.17305/bjbms.2012.2445