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Chromatin accessibility promotes hematopoietic and leukemia stem cell activity
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- Chromatin accessibility is a key mediator of gene expression and mutations in chromatin modifiers are frequently seen in cancers. Here, the authors show that the chromatin accessibility regulator HMGN1 - which is frequently mutated by amplification in leukemias - acts by blocking myeloid differentiation.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f424d9b406fb49f7a429fe6474f60a2d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-020-15221-z