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A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine
- Source :
- Brazilian Journal of Medical and Biological Research, Vol 55 (2022)
- Publication Year :
- 2022
- Publisher :
- Associação Brasileira de Divulgação Científica, 2022.
-
Abstract
- The Goto-Kakizaki (GK) rat is a non-obese experimental model of type 2 diabetes mellitus (T2DM) that allows researchers to monitor diabetes-induced changes without jeopardizing the effects of obesity. This rat strain exhibits notable gastrointestinal features associated with T2DM, such as marked alterations in intestinal morphology, reduced intestinal motility, slow transit, and modified microbiota compared to Wistar rats. The primary treatments for diabetic patients include administration of hypoglycemic agents and insulin, and lifestyle changes. Emerging procedures, including alternative therapies, metabolic surgeries, and modulation of the intestinal microbiota composition, have been shown to improve the diabetic state of GK rats. This review describes the morpho-physiological diabetic-associated features of the gastrointestinal tract (GIT) of GK rats. We also describe promising strategies, e.g., metabolic surgery and modulation of gut microbiota composition, used to target the GIT of this animal model to improve the diabetic state.
Details
- Language :
- English
- ISSN :
- 1414431X and 1414431x
- Volume :
- 55
- Database :
- Directory of Open Access Journals
- Journal :
- Brazilian Journal of Medical and Biological Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f3e78aa7f1433cb7c8aa3cd0f3d7ce
- Document Type :
- article
- Full Text :
- https://doi.org/10.1590/1414-431x2022e11910