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ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells
- Source :
- Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
- Publication Year :
- 2023
- Publisher :
- Nature Portfolio, 2023.
-
Abstract
- The metastability of stem cells requires a mechanism for actively blocking dedifferentiation to achieve successful differentiation. Here the authors show that ZBTB12 serves as a molecular barrier to dedifferentiation by repressing a primate-specific retrotransposon, HERVH.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 14
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f3e07482fc9142a28b133dbf0b354992
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-023-36178-9