Comparative Effects of Direct Renin Inhibitor and Angiotensin Receptor Blocker on Albuminuria in Hypertensive Patients with Type 2 Diabetes. A Randomized Controlled Trial.

Authors :: Takashi Uzu
Shin-Ichi Araki
Atsunori Kashiwagi
Masakazu Haneda
Daisuke Koya
Hiroki Yokoyama
Yasuo Kida
Motoyoshi Ikebuchi
Takaaki Nakamura
Masataka Nishimura
Noriko Takahara
Toshiyuki Obata
Nobuyuki Omichi
Katsuhiko Sakamoto
Ryosuke Shingu
Hideki Taki
Yoshio Nagai
Hiroaki Tokuda
Munehiro Kitada
Miwa Misawa
Akira Nishiyama
Hiroyuki Kobori
Hiroshi Maegawa
Shiga Committee for Preventing Diabetic Nephropathy
Source :: PLoS ONE, Vol 11, Iss 12, p e0164936 (2016)
Publication Year :: 2016
Publisher :: Public Library of Science (PLoS), 2016.
Abstract: In patients with diabetes, albuminuria is a risk marker of end-stage renal disease and cardiovascular events. An increased renin-angiotensin system activity has been reported to play an important role in the pathological processes in these conditions. We compared the effect of aliskiren, a direct renin inhibitor (DRI), with that of angiotensin receptor blockers (ARBs) on albuminuria and urinary excretion of angiotensinogen, a marker of intrarenal renin-angiotensin system activity.We randomly assigned 237 type 2 diabetic patients with high-normal albuminuria (10 to

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