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COVIDTrach: a prospective cohort study of mechanically ventilated patients with COVID-19 undergoing tracheostomy in the UK

Authors :
A Thompson
S Wilkinson
N Kumar
G Wong
J Smith
F Franco
P Smith
A Wilson
S Ghosh
S Shepherd
A Kumar
R Brown
D Williams
M Griffiths
J Sen
M Roberts
A McGrath
D Kumar
A Walker
A Gupta
N Sharma
P Shah
M Kumar
H Jones
P Paul
I Gonzalez
A Shah
V Srinivasan
M Kelly
P Surda
K Valchanov
S Saha
R Bentley
C Hall
J Ng
C Pearce
R Harris
H Wilson
N Amin
J Phillips
D Park
C Jennings
L Wren
B McGrath
D Walker
J Ahmed
S Menon
N Jain
R Mistry
E Jackson
W Rutherford
E France
S Mahalingam
C Hogan
A Burns
T Exall
J Rodrigues
C Xie
M Rouhani
E Paramasivam
A WILLIAMSON
K STEELE
D Dawson
S Linton
M Cameron
S Biswas
S Hodges
J Collier
J Collins
S Bennett
T Ali
N Bhatti
S Suresh
J Williamson
G Ambler
C Cook
D Baker
J Bates
J Blair
P Mukherjee
A Howard
B Cosway
M Anwar
S Fang
S Meghji
H Griffiths
M Keil
F GREEN
K Hussain
A Schache
C Lockie
S Winter
J Westwood
A Hormis
P Ward
C Walker
G Sandhu
T Davies
A Lloyd
L Linhartova
C SPENCER
A Courtney
L Bates
T Martín
T Tatla
L Ritchie
P Gill
S Shannon
A Arora
R Pinto
H Turner
J Whittaker
E Warner
L Leach
A Menon
J Higginson
G Warner
A Balfour
F Cooper
A Li
S Berry
R Gohil
M Celinski
J McEwan
E Riley
S Webster
I Ahmad
M Idle
K Jolly
S Burrows
S Parmar
B Morris
A Arya
S Mustafa
E Tam
D Chakravarty
M De
A Daudia
B Tehan
R Temple
J Broad
P Andrews
D Pennell
C Smart
R D’Souza
P Praveen
DJ Lin
M Osborne
A Coombs
T Hunt
M Singer
C Smyth
R Saha
G Walton
P Bishop
U Sheikh
R O'Brien
R Bhandari
A Rovira
S Sanyal
E Yeung
A Tse
N Lawrence
P Stimpson
H Saeed
K Fan
M Ashcroft
T Jacob
J Hadley
K Goodwin
Z Abdi
D Nair
B Hill
D Whitmore
N Macartney
P Sykes
N Mercer
R Sykes
S Siddiq
Nick JI Hamilton
AGM Schilder
MM George
GM Jama
J Goulder
C Schilling
S Laha
MA Birchall
NS Tolley
P Nankivell
O Breik
P Pracy
J Osher
C Huppa
P Stenhouse
F Ryba
EK Bhargava
D Ranford
A Takhar
C Tornari
M Verkerk
C Al-Yaghchi
M Jaafar
N Cereceda-Monteoliva
A Holroyd
K Ghufoor
H O'Mahony
H Drewery
A Mulcahy
T Magos
I Balasundaram
M Heliotis
A Loizidou
D York
R Exley
KA Solanki
P Kirticumar
A Shirazian
Y Bhatt
R Natt
N Banga
K Dhadwal
I Ekpemi
R Roplekar-Bance
N Glibbery
K Karamali
T Munroe-Gray
P Sethukumar
R Vasanthan
H Lee-Six
B Misztal
S Millington
M Musalia
A Cardozo
M Dunbobbin
S Shahidi
M Chachlani
J Fussey
M Misurati
S Ashok
H Aboulgheit
S Khwaja
R Anmolsingh
B Al-Dulaimy
E Omakobia
T Browning
L Lignos
P Twose
J Heyman
D Kathwadia
T Hwara
O Judd
W Parker
TP Davis
T Stubington
H Koumoullis
E Willcocks
L Skelly
G Dempsey
K Liatsikos
B Borgatta
A Glossop
V Politidis
D Dhariwal
A Kara
G Tattersall
W Udall
P Kirkland
J Staufenberg
H Buglass
NW Wahid
A Amlani
P Deutsch
K Markham
O Barker
A Easthope
S Glaze
D Bondin
D Thorley
K Kapoor
S Sirajuddin
F van Damme
O Mattoo
E Kershaw
S Dewhurst
S Blakeley
C Chivers
L Lindsey
R Glore
H Cunniffe
D Moult
D Zolger
J Bakmanidis
S Kandiah
A Pericleous
R Sheikh
U Nagalotimath
E El-Tabal
S Ghaffar
M Dallison
E Leakey
O Sanders
A Gomati
L Moir
CB Groba
C Davies-Husband
N Seymour
R Lovett
J Lunn
A Armson
K Hilliard
S Ladan
P Tsirevelou
V Ratnam
A Muddaiah
J Coakes
R Borg
A Tsagkovits
O Mulla
N Stobbs
D Pratap
Z Ghani
J Rocke
S Snape
A Hassaan
S Beckett
R Siau
C Lamont
C Blore
D Zakai
R Moorthy
P Bothma
A Syndercombe
N Keates
M Junaid
T Antonio
A Vijendren
V Venkatachalam
M Lechner
D Chandrasekharan
J Whiteside
S Dennis
A Eldahshan
H Paw
M Colomo-Gonzalez
N Mani
B Ranganathan
N Amiruddin
A Sladkowski
AK Abou-Foul
S Kishwan
P Naredla
A Al-Ajami
S Okhovat
E Carey
N Vallabh
A. Alatsatianos
R Townsley
Source :
BMJ Surgery, Interventions, & Health Technologies, Vol 3, Iss 1 (2021)
Publication Year :
2021
Publisher :
BMJ Publishing Group, 2021.

Abstract

Objectives COVIDTrach is a UK multicentre prospective cohort study project that aims to evaluate the outcomes of tracheostomy in patients with COVID-19 receiving mechanical ventilation and record the incidence of SARS-CoV-2 infection among healthcare workers involved in the procedure.Design Data on patient demographic, clinical history and outcomes were entered prospectively and updated over time via an online database (REDCap). Clinical variables were compared with outcomes, with logistic regression used to develop a model for mortality. Participants recorded whether any operators tested positive for SARS-CoV-2 within 2 weeks of the procedure.Setting UK National Health Service departments involved in treating patients with COVID-19 receiving mechanical ventilation.Participants The cohort comprised 1605 tracheostomy cases from 126 UK hospitals collected between 6 April and 26 August 2020.Main outcome measures Mortality following tracheostomy, successful wean from mechanical ventilation and length of time from tracheostomy to wean, discharge from hospital, complications from tracheostomy, reported SARS-CoV-2 infection among operators.Results The median time from intubation to tracheostomy was 15 days (IQR 11, 21). 285 (18%) patients died following the procedure. 1229 (93%) of the survivors had been successfully weaned from mechanical ventilation at censoring and 1049 (81%) had been discharged from hospital. Age, inspired oxygen concentration, positive end-expiratory pressure setting, fever, number of days of ventilation before tracheostomy, C reactive protein and the use of anticoagulation and inotropic support independently predicted mortality. Six reports were received of operators testing positive for SARS-CoV-2 within 2 weeks of the procedure.Conclusions Tracheostomy appears to be safe in mechanically ventilated patients with COVID-19 and to operators performing the procedure and we identified clinical parameters that are predictive of mortality.Trial registration number The study is registered with ClinicalTrials.Gov (NCT04572438).

Details

Language :
English
ISSN :
26314940
Volume :
3
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMJ Surgery, Interventions, & Health Technologies
Publication Type :
Academic Journal
Accession number :
edsdoj.f39254fc256c44baa7da4198d37da5ef
Document Type :
article
Full Text :
https://doi.org/10.1136/bmjsit-2020-000077