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Stereoselective OsO4-mediated dihydroxylation of β-substituted α-trialkylsilyl-β,γ-unsaturated esters
- Source :
- Results in Chemistry, Vol 3, Iss , Pp 100250- (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- The dihydroxylation of various of α-trialkylsilyl-β,γ-unsaturated esters with OsO4 and NMO has been explored. It has been revealed that these reactions readily allow for a stereoselective dihydroxylation with high levels of dr (>20/1) to afford anti-aldol products with three contiguous stereogenic centers in modest overall yields.
Details
- Language :
- English
- ISSN :
- 22117156
- Volume :
- 3
- Issue :
- 100250-
- Database :
- Directory of Open Access Journals
- Journal :
- Results in Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f35a48c8c5e8410a87c28e5865ff6a7f
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.rechem.2021.100250