NEONATAL THROMBOCYTOPENIC PURPURA: REPORT OF TWO CASES AND REVIEW OF LITERATURE

Introduction: Severe neonatal thrombocytopenia is a hematological emergency that can be due to increased platelet destruction (such as immune-mediated and peripheral platelet consumption) or congenital failure of platelet production. The definitive diagnosis of the underlying cause of neonatal thrombocytopenic purpura is based on both clinical and laboratory findings. Case report: We present two infants with persistent severe thrombocytopenia of distinct aetiologies: neonatal alloimmune thrombocytopenic purpura and hepatitis B virus exposure. Their clinical course, haematological profile and treatments are discussed. Conclusion: This report reiterates the need to think laterally while considering the differential diagnoses of neonatal thrombocytopenic purpura. Moreover, it highlights its treatment challenges in peripheral health facilities, especially in resource-limited settings