THE PRACTICE OF MANAGING THE PATIENTS WITH INFECTIVE ENDOCARDITIS IN THE RUSSIAN FEDERATION

The data of a multicenter study of the etiology, antibiotic susceptibility, and pharmacoepidemiology of infective endocarditis in 10 regions of Russia is presented. The aim of the study was to analyse the diagnostication and antibacterial therapy in patients with infectious endocarditis. Patients of both sexes and all age groups with a definite and probable infective endocarditis were enrolled in the study. 406 cases of infectious endocarditis were analysed (106 prospective and 240 retrospective). The etiologically valid pathogen was isolated from 144 cases (35.5%). Grampositive cocci (90.3%), mainly S.aureus (46.5% of the all the isolates) prevailed. In the starting antibacterial therapy the most frequent drugs were aminoglycosides (22.8%) and the 3rd generation parenteral cephalosporins (22.1%). With the change of antibacterial therapy, glycopeptides were more often prescribed - 18.6% of cases.