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Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential
- Source :
- Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
- Publication Year :
- 2016
- Publisher :
- Nature Portfolio, 2016.
-
Abstract
- The developmental potential of mosaic embryos of euploid and aneuploid cells is unknown. Here, the authors create a mouse model of chromosome mosaicism, showing that aneuploid cells in the fetus are eliminated by apoptosis and developmental potential is dependent on the presence of sufficient euploid cells.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f312396394384d1dacdd38a6e94d0540
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms11165