Back to Search
Start Over
Store-Operated Calcium Entry and Its Implications in Cancer Stem Cells
- Source :
- Cells, Vol 11, Iss 8, p 1332 (2022)
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- Tumors are composed by a heterogeneous population of cells. Among them, a sub-population of cells, termed cancer stem cells, exhibit stemness features, such as self-renewal capabilities, disposition to differentiate to a more proliferative state, and chemotherapy resistance, processes that are all mediated by Ca2+. Ca2+ homeostasis is vital for several physiological processes, and alterations in the patterns of expressions of the proteins and molecules that modulate it have recently become a cancer hallmark. Store-operated Ca2+ entry is a major mechanism for Ca2+ entry from the extracellular medium in non-excitable cells that leads to increases in the cytosolic Ca2+ concentration required for several processes, including cancer stem cell properties. Here, we focus on the participation of STIM, Orai, and TRPC proteins, the store-operated Ca2+ entry key components, in cancer stem cell biology and tumorigenesis.
- Subjects :
- store-operated calcium entry
Orai1
cancer stem cells
Cytology
QH573-671
Subjects
Details
- Language :
- English
- ISSN :
- 20734409 and 12928267
- Volume :
- 11
- Issue :
- 8
- Database :
- Directory of Open Access Journals
- Journal :
- Cells
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f2c9317313f44cafb31587a129282674
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/cells11081332