Tissue-level alveolar epithelium model for recapitulating SARS-CoV-2 infection and cellular plasticity

Yang et al. present an alveolar cell culture method that utilizes primary human alveolar epithelial cells, culturing cells in a small-molecule cocktail supplemented media. The authors show that the longevity of the primary cells culture can be expanded, and study human alveolar development, infection, injury repair, while demonstrating its use for SARS-CoV-2 infection.