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2-Propyl-N′-[1,7,7-trimethylbicyclo[2.2.1]hept-2-ylidene]pentanehydrazide
- Source :
- Molbank, Vol 2020, Iss 4, p M1164 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- 2-Propyl-N′-[1,7,7-trimethylbicyclo[2.2.1]hept-2-ylidene]pentanehydrazide was obtained in 80% yield via the Einhorn variation of the Schotten–Baumann method by (+)-camphor hydrazide condensation with valproic acid (VPA) chloride. The structure of the titled compound was verified by Raman, FTIR, 1H-NMR, and 13C-NMR spectral analysis along with FAB-mass spectrometry. Thermal properties of synthesized derivative were elucidated by DSC and its purity by HPLC. The compound was successfully tested as a potential anticonvulsant agent based on models of chemically- and electrically-induced seizures.
Details
- Language :
- English
- ISSN :
- 14228599
- Volume :
- 2020
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Molbank
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f22ff1267fcf4bbe8ceff4a1ede25c91
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/M1164