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2-Propyl-N′-[1,7,7-trimethylbicyclo[2.2.1]hept-2-ylidene]pentanehydrazide

Authors :
Mariia Nesterkina
Dmytro Barbalat
Ildar Rakipov
Iryna Kravchenko
Source :
Molbank, Vol 2020, Iss 4, p M1164 (2020)
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

2-Propyl-N′-[1,7,7-trimethylbicyclo[2.2.1]hept-2-ylidene]pentanehydrazide was obtained in 80% yield via the Einhorn variation of the Schotten–Baumann method by (+)-camphor hydrazide condensation with valproic acid (VPA) chloride. The structure of the titled compound was verified by Raman, FTIR, 1H-NMR, and 13C-NMR spectral analysis along with FAB-mass spectrometry. Thermal properties of synthesized derivative were elucidated by DSC and its purity by HPLC. The compound was successfully tested as a potential anticonvulsant agent based on models of chemically- and electrically-induced seizures.

Details

Language :
English
ISSN :
14228599
Volume :
2020
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Molbank
Publication Type :
Academic Journal
Accession number :
edsdoj.f22ff1267fcf4bbe8ceff4a1ede25c91
Document Type :
article
Full Text :
https://doi.org/10.3390/M1164