Serum proteomics links suppression of tumor immunity to ancestry and lethal prostate cancer

Authors :: Tsion Zewdu Minas
Julián Candia
Tiffany H. Dorsey
Francine Baker
Wei Tang
Maeve Kiely
Cheryl J. Smith
Amy L. Zhang
Symone V. Jordan
Obadi M. Obadi
Anuoluwapo Ajao
Yao Tettey
Richard B. Biritwum
Andrew A. Adjei
James E. Mensah
Robert N. Hoover
Frank J. Jenkins
Rick Kittles
Ann W. Hsing
Xin W. Wang
Christopher A. Loffredo
Clayton Yates
Michael B. Cook
Stefan Ambs
Source :: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Publication Year :: 2022
Publisher :: Nature Portfolio, 2022.
Abstract: Ancestry-related differences in immunobiology may explain the health disparities observed in prostate cancer patients, with men of African origin bearing the highest prostate cancer burden. By measuring immune-related proteins in serum samples, here the authors report that systemic cytokines linked to suppression of tumor immunity are upregulated in men of African ancestry and associated with reduced survival.

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