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Structural basis for the target specificity of actin histidine methyltransferase SETD3

Authors :
Shaobo Dai
John R. Horton
Clayton B. Woodcock
Alex W. Wilkinson
Xing Zhang
Or Gozani
Xiaodong Cheng
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

SETD3 is the first known metazoan protein histidine methyltransferase but the molecular basis for its target specificity is unclear. Here, the authors elucidate the structural and molecular determinants for the histidine specificity of SETD3.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.f2129526184a4597af28ea92c757a4b4
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-11554-6