Back to Search
Start Over
Genetic Characterization and Enhanced Surveillance of Ceftriaxone-Resistant Neisseria gonorrhoeae Strain, Alberta, Canada, 2018
- Source :
- Emerging Infectious Diseases, Vol 25, Iss 9, Pp 1660-1667 (2019)
- Publication Year :
- 2019
- Publisher :
- Centers for Disease Control and Prevention, 2019.
-
Abstract
- In July 2018, a case of Neisseria gonorrhoeae associated with ceftriaxone treatment failure was identified in Alberta, Canada. We identified the isolate and nucleic acid amplification testing (NAAT) specimen as the ceftriaxone-resistant strain multilocus sequence type 1903/NG-MAST 3435/NG-STAR 233, originally identified in Japan (FC428), with the same penA 60.001 mosaic allele and genetic resistance determinants. Core single-nucleotide variant (SNV) analysis identified 13 SNVs between this isolate and FC428. Culture-independent surveillance by PCR for the A311V mutation in the penA allele and N. gonorrhoeae multiantigen sequence typing directly from NAAT transport media positive for N. gonorrhoeae by NAAT did not detect spread of the strain. We identified multiple sequence types not previously detected in Alberta by routine surveillance. This case demonstrates the benefit of using culture-independent methods to enhance detection, public health investigations, and surveillance to address this global threat.
Details
- Language :
- English
- ISSN :
- 10806040 and 10806059
- Volume :
- 25
- Issue :
- 9
- Database :
- Directory of Open Access Journals
- Journal :
- Emerging Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f1d81a5818b4a12bfe0df49683887db
- Document Type :
- article
- Full Text :
- https://doi.org/10.3201/eid2509.190407