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Targeting ferroptosis in osteosarcoma

Targeting ferroptosis in osteosarcoma

Authors :
Jiazheng Zhao
Yi Zhao
Xiaowei Ma
Benzheng Zhang
Helin Feng
Source :
Journal of Bone Oncology, Vol 30, Iss , Pp 100380- (2021)
Publication Year :
2021
Publisher :
Elsevier, 2021.

Abstract

Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents, with high degree of malignancy and an extremely poor prognosis. Ferroptosis, a non-traditional mode of regulated cell death (RCD) characterised by iron-dependent accumulation of lipid reactive oxygen species (ROS), is closely associated with a variety of cancers. It has been demonstrated that ferroptosis can regulate OS progression and exert an essential role in the treatment of OS, which is potentially of great value. By targeting ferroptosis in OS, the present review article summarises the relevant mechanisms and therapeutic applications along with discussing current limitations and future directions, which may provide a new strategy for the treatment of OS.

Details

Language :
English
ISSN :
22121374
Volume :
30
Issue :
100380-
Database :
Directory of Open Access Journals
Journal :
Journal of Bone Oncology
Publication Type :
Academic Journal
Accession number :
edsdoj.f1b66a9cb9634076bb8aefcd619c51cf
Document Type :
article
Full Text :
https://doi.org/10.1016/j.jbo.2021.100380