Back to Search
Start Over
Targeting ferroptosis in osteosarcoma
Targeting ferroptosis in osteosarcoma
- Source :
- Journal of Bone Oncology, Vol 30, Iss , Pp 100380- (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Osteosarcoma (OS) is the most common primary bone tumour in children and adolescents, with high degree of malignancy and an extremely poor prognosis. Ferroptosis, a non-traditional mode of regulated cell death (RCD) characterised by iron-dependent accumulation of lipid reactive oxygen species (ROS), is closely associated with a variety of cancers. It has been demonstrated that ferroptosis can regulate OS progression and exert an essential role in the treatment of OS, which is potentially of great value. By targeting ferroptosis in OS, the present review article summarises the relevant mechanisms and therapeutic applications along with discussing current limitations and future directions, which may provide a new strategy for the treatment of OS.
Details
- Language :
- English
- ISSN :
- 22121374
- Volume :
- 30
- Issue :
- 100380-
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Bone Oncology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f1b66a9cb9634076bb8aefcd619c51cf
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jbo.2021.100380