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Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis
- Source :
- International Journal of Molecular Sciences, Vol 15, Iss 6, Pp 10136-10149 (2014)
- Publication Year :
- 2014
- Publisher :
- MDPI AG, 2014.
-
Abstract
- Three pregnane-type steroids, including a new metabolite, 3β-methoxy-5,20-pregnadiene (1) along with two known analogues, 3β-acetoxy-5,20-pregnadiene (2) and 5α-pregna-1,20-dien-3-one (3) were isolated from the soft coral Scleronephthya flexilis. Standard spectroscopic techniques were used to determine the structure of new steroid 1. The absolute stereochemistry of steroid 2 was confirmed by X-ray diffraction analysis. Steroid 3 exhibited potent activity against MOLT-4 tumor cells.
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 15
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f1a80ed0c9af40d3ba2a8cccad75ac0c
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/ijms150610136