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Human beige adipocytes for drug discovery and cell therapy in metabolic diseases

Authors :
Amar M. Singh
Liang Zhang
John Avery
Amelia Yin
Yuhong Du
Hui Wang
Zibo Li
Haian Fu
Hang Yin
Stephen Dalton
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Methods to generate beige adipocytes from a human cell source are inefficient. Here, the authors present a protocol that efficiently generates beige adipocytes from human adipose-derived stem cells (ADSCs), which have potential utility in therapeutic development relating to metabolic diseases such as type 2 diabetes.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.f1a0bcf1ec452dab09549896e69ef7
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-16340-3