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Interruption of aberrant chromatin looping is required for regenerating RB1 function and suppressing tumorigenesis
- Source :
- Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- A CTCF mediated intrachromosomal looping of RB1 promoter and its downstream silencer served as a regulatory inducer to inactivate RB1, revealing a novel transcriptional mechanism underlying RB1 dysfunction independent of gene mutation.
- Subjects :
- Biology (General)
QH301-705.5
Subjects
Details
- Language :
- English
- ISSN :
- 23993642
- Volume :
- 5
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Communications Biology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f19ac3a806ca4678bdf06ddb49a31121
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s42003-022-04007-2