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NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- Improper innate sensing within the tumor microenvironment limits immunotherapy success. Here, the authors show that targeting NQO1 triggers immunogenic innate sensing to reactivate T cells and overcome immune checkpoint blockade resistance.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723 and 20985045
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f18e4e20985045188e6e4ba9bb61cc6d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-11238-1