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Diagnostic Challenges and Prospects Associated With Zoonotic Tuberculosis of Central Nervous System
- Source :
- Basic and Clinical Neuroscience, Vol 11, Iss 5, Pp 619-630 (2020)
- Publication Year :
- 2020
- Publisher :
- Iran University of Medical Sciences, 2020.
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Abstract
- Introduction: The diagnosis of Tuberculous Meningitis (TBM) has remained a challenge due to its insidious onset and the failure of conventional diagnostic tests. The present study aimed to identify the mycobacterial pathogen in the CSF of patients with TBM and a poor prognosis. Methods: We retrospectively recruited 224 TBM and 34 non-TBM patients admitted to the Central India Institute of Medical Sciences, Nagpur, India, in 2014. The CSF samples of these patients were subjected to a duplex PCR assay for the species-specific identification of the causative pathogen. Results: M. bovis and infection with M.tuberculosis were detected in 7% (18) and 32.9% (85) of the patients, respectively. Moreover, 14% (36) of the study samples were culture positive; however, the mycobacterial pathogens could not be differentiated to the species level. Conclusion: The present study findings emphasized the potentially vital importance of M. bovis identification for appropriate patient management. The obtained data also demonstrated the persistent significance of M. bovis, as a zoonotic pathogen.
Details
- Language :
- English
- ISSN :
- 2008126X and 22287442
- Volume :
- 11
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- Basic and Clinical Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f1871099089b47a98fe03b3aace972aa
- Document Type :
- article