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Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism
- Source :
- Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Portfolio, 2017.
-
Abstract
- How neurons and neuronal activity regulate astrocyte functions is poorly understood. Haselet al. identify two large groups of astrocytic genes that are regulated by neuronal contact and synaptic activity respectively, with distinct roles in astrocytic function; interestingly, many of these genes are dysregulated in neurodegeneration.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723 and 82484929
- Volume :
- 8
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f17cb8505a5e4abe82484929859194ff
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms15132