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Stimulation of epidermal hyperplasia and tumorigenesis by resident p16INK4a-expressing cells
- Source :
- Molecular & Cellular Oncology, Vol 7, Iss 6 (2020)
- Publication Year :
- 2020
- Publisher :
- Taylor & Francis Group, 2020.
-
Abstract
- p16INK4a (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16INK4a in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes. The study suggests a pro-tumorigenic function of p16INK4a in early epidermal lesions, which could potentially be targeted by senolytic therapy.
Details
- Language :
- English
- ISSN :
- 23723556
- Volume :
- 7
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Molecular & Cellular Oncology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f142b1dcbc0c4b5d8a0f038034358e87
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/23723556.2020.1819752