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Diabetes, Obesity, and Inflammation: Impact on Clinical and Radiographic Features of Breast Cancer

Authors :
Braden Miller
Hunter Chalfant
Alexandra Thomas
Elizabeth Wellberg
Christina Henson
Molly W. McNally
William E. Grizzle
Ajay Jain
Lacey R. McNally
Source :
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2757 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Obesity, diabetes, and inflammation increase the risk of breast cancer, the most common malignancy in women. One of the mainstays of breast cancer treatment and improving outcomes is early detection through imaging-based screening. There may be a role for individualized imaging strategies for patients with certain co-morbidities. Herein, we review the literature regarding the accuracy of conventional imaging modalities in obese and diabetic women, the potential role of anti-inflammatory agents to improve detection, and the novel molecular imaging techniques that may have a role for breast cancer screening in these patients. We demonstrate that with conventional imaging modalities, increased sensitivity often comes with a loss of specificity, resulting in unnecessary biopsies and overtreatment. Obese women have body size limitations that impair image quality, and diabetes increases the risk for dense breast tis-sue. Increased density is known to obscure the diagnosis of cancer on routine screening mammography. Novel molecu-lar imaging agents with targets such as estrogen receptor, human epidermal growth factor receptor 2 (HER2), pyrimi-dine analogues, and ligand-targeted receptor probes, among others, have potential to reduce false positive results. They can also improve detection rates with increased resolution and inform therapeutic decision making. These emerg-ing imaging techniques promise to improve breast cancer diagnosis in obese patients with diabetes who have dense breasts, but more work is needed to validate their clinical application.

Details

Language :
English
ISSN :
14220067 and 16616596
Volume :
22
Issue :
5
Database :
Directory of Open Access Journals
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.f13f9d8d1848cfb0022204d9aab84a
Document Type :
article
Full Text :
https://doi.org/10.3390/ijms22052757