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Observation of Palatal Wound Healing Process Following Various Degrees of Mucoperiosteal and Bone Trauma in a Young Rat Model

Authors :
Yingmeng Liu
Shiming Zhang
Karim Ahmed Sakran
Jiayi Yin
Min Lan
Chao Yang
Yan Wang
Ni Zeng
Hanyao Huang
Bing Shi
Source :
Biology, Vol 11, Iss 8, p 1142 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

The accidental injury or surgery on soft and hard palatal tissue has an adverse impact on normal maxillary morphology. To design a single-factor experiment that excludes other interfering factors on maxillary growth, a young rat model was established to simulate the various degrees of palatal trauma. Eight maxillary parameters were measured to evaluate the impact of palatal trauma on maxillary growth. Furthermore, the acellular dermal matrix (ADM) was applied to cure the palatal trauma and alleviate the adverse impact of bone denudation on the maxillary growth. Micro-CT scanning and histology analyses were used. One-way ANOVA with least significant difference (LSD) post-test was used to evaluate the statistical significance. The palatal trauma mainly disturbed the transverse development of the maxilla. ADM promotes mucosa healing, but there is still an inhibitory effect on maxillofacial growth.

Details

Language :
English
ISSN :
20797737
Volume :
11
Issue :
8
Database :
Directory of Open Access Journals
Journal :
Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.f12df28210994eb58e25dcc0b7df335b
Document Type :
article
Full Text :
https://doi.org/10.3390/biology11081142