Back to Search Start Over

The Role of CCL3 in the Pathogenesis of Rheumatoid Arthritis

Authors :
Ying-Li Yang
Xiao-Feng Li
Biao Song
Sha Wu
Yuan-Yuan Wu
Cheng Huang
Jun Li
Source :
Rheumatology and Therapy, Vol 10, Iss 4, Pp 793-808 (2023)
Publication Year :
2023
Publisher :
Adis, Springer Healthcare, 2023.

Abstract

Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease of unexplained causes. Its pathological features include synovial tissue hyperplasia, inflammatory cell infiltration in joint cavity fluid, cartilage bone destruction, and joint deformation. C–C motif chemokine ligand 3 (CCL3) belongs to inflammatory cell chemokine. It is highly expressed in inflammatory immune cells. Increasingly, studies have shown that CCL3 can promote the migration of inflammatory factors to synovial tissue, the destruction of bone and joint, angiogenesis, and participate in the pathogenesis of RA. These symptoms indicate that the expression of CCL3 is highly correlated with RA disease. Therefore, this paper reviews the possible mechanism of CCL3 in the pathogenesis of RA, which may provide some new insights for the diagnosis and treatment of RA.

Details

Language :
English
ISSN :
21986576 and 21986584
Volume :
10
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Rheumatology and Therapy
Publication Type :
Academic Journal
Accession number :
edsdoj.f128d3b801b24b88a6ffa92d13c16c81
Document Type :
article
Full Text :
https://doi.org/10.1007/s40744-023-00554-0