Back to Search
Start Over
The Role of CCL3 in the Pathogenesis of Rheumatoid Arthritis
- Source :
- Rheumatology and Therapy, Vol 10, Iss 4, Pp 793-808 (2023)
- Publication Year :
- 2023
- Publisher :
- Adis, Springer Healthcare, 2023.
-
Abstract
- Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease of unexplained causes. Its pathological features include synovial tissue hyperplasia, inflammatory cell infiltration in joint cavity fluid, cartilage bone destruction, and joint deformation. C–C motif chemokine ligand 3 (CCL3) belongs to inflammatory cell chemokine. It is highly expressed in inflammatory immune cells. Increasingly, studies have shown that CCL3 can promote the migration of inflammatory factors to synovial tissue, the destruction of bone and joint, angiogenesis, and participate in the pathogenesis of RA. These symptoms indicate that the expression of CCL3 is highly correlated with RA disease. Therefore, this paper reviews the possible mechanism of CCL3 in the pathogenesis of RA, which may provide some new insights for the diagnosis and treatment of RA.
Details
- Language :
- English
- ISSN :
- 21986576 and 21986584
- Volume :
- 10
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Rheumatology and Therapy
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f128d3b801b24b88a6ffa92d13c16c81
- Document Type :
- article
- Full Text :
- https://doi.org/10.1007/s40744-023-00554-0