Back to Search Start Over

Elucidating Iron Metabolism through Molecular Imaging

Authors :
Feifei Liao
Wenwen Yang
Linzi Long
Ruotong Yu
Hua Qu
Yuxuan Peng
Jieming Lu
Chenghuan Ren
Yueqi Wang
Changgeng Fu
Source :
Current Issues in Molecular Biology, Vol 46, Iss 4, Pp 2798-2818 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Iron is essential for many physiological processes, and the dysregulation of its metabolism is implicated in the pathogenesis of various diseases. Recent advances in iron metabolism research have revealed multiple complex pathways critical for maintaining iron homeostasis. Molecular imaging, an interdisciplinary imaging technique, has shown considerable promise in advancing research on iron metabolism. Here, we comprehensively review the multifaceted roles of iron at the cellular and systemic levels (along with the complex regulatory mechanisms of iron metabolism), elucidate appropriate imaging methods, and summarize their utility and fundamental principles in diagnosing and treating diseases related to iron metabolism. Utilizing molecular imaging technology to deeply understand the complexities of iron metabolism and its critical role in physiological and pathological processes offers new possibilities for early disease diagnosis, treatment monitoring, and the development of novel therapies. Despite technological limitations and the need to ensure the biological relevance and clinical applicability of imaging results, molecular imaging technology’s potential to reveal the iron metabolic process is unparalleled, providing new insights into the link between iron metabolism abnormalities and various diseases.

Details

Language :
English
ISSN :
14673045 and 14673037
Volume :
46
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Current Issues in Molecular Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.f0cc53c7bd7d4b7b9c4fa3f2e46aed29
Document Type :
article
Full Text :
https://doi.org/10.3390/cimb46040175