Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum

Authors :: Timothy N. Tiambeng
David S. Roberts
Kyle A. Brown
Yanlong Zhu
Bifan Chen
Zhijie Wu
Stanford D. Mitchell
Tania M. Guardado-Alvarez
Song Jin
Ying Ge
Source :: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Publication Year :: 2020
Publisher :: Nature Portfolio, 2020.
Abstract: Top-down proteomics can provide unique insights into the biological variations of protein biomarkers but detecting low-abundance proteins in body fluids remains challenging. Here, the authors develop a nanoparticle-based top-down proteomics approach enabling enrichment and detailed analysis of cardiac troponin I in human serum.

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