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Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review

Authors :
Yuanrui Luo
Minghao Sun
Linyun Tan
Tao Li
Li Min
Source :
Pharmaceutics, Vol 15, Iss 12, p 2717 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Osteosarcoma, a predominant malignant bone tumor, poses significant challenges due to its high metastatic and recurrent nature. Although various therapeutic strategies are currently in use, they often inadequately target osteosarcoma metastasis. This review focuses on the potential of nanoscale drug delivery systems to bridge this clinical gap. It begins with an overview of the molecular mechanisms underlying metastatic osteosarcoma, highlighting the limitations of existing treatments. The review then transitions to an in-depth examination of nanoscale drug delivery technologies, emphasizing their potential to enhance drug bioavailability and reduce systemic toxicity. Central to this review is a discussion of recent advancements in utilizing nanotechnology for the potential intervention of metastatic osteosarcoma, with a critical analysis of several preclinical studies. This review aims to provide insights into the potential applications of nanotechnology in metastatic osteosarcoma therapy, setting the stage for future clinical breakthroughs and innovative cancer treatments.

Details

Language :
English
ISSN :
19994923
Volume :
15
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Pharmaceutics
Publication Type :
Academic Journal
Accession number :
edsdoj.f0ae7d2c4dcf8cb85ddcc19e1a09
Document Type :
article
Full Text :
https://doi.org/10.3390/pharmaceutics15122717