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Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus
- Source :
- Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Portfolio, 2017.
-
Abstract
- Wnt proteins mediate embryonic development but how protein localization and patterning is regulated is unclear. Here, the authors show that distinct structures with different heparan sulfate modifications (‘N-sulfo-rich’ and ‘N-acetyl-rich’) regulate cellular localization and signal transduction of Wnt8 in Xenopus.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 8
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.f0792f5891d54f889587aed241efe068
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-017-02076-0